Oriental Raisin Tree (also known as Holvenia Dulcis, Dihydromyricetin and DHM)*
Dihydromyricetin (DHM), one of the most powerful substances in BoozAid, is harvested from the Holvenia Dulcis plant.
In Asia, for over a thousand years, this plant has been used to brew a hangover tea. Only recently has the active ingredient, Dihydromyricetin (DHM), been isolated and extracted from the Holvenia Dulcis plant.
Dihydromyricetin (DHM) has been shown to reduce hangovers in three different ways:
- It rids the liver of highly toxic acetaldehyde by helping to break it down. With the aggression of DHM, this toxic substance exits the body quicker, thus lessening the severity of the aftermath of excessive alcohol consumption.
- It helps to alleviate the state of “hyper-excitability” (i.e. short-term alcohol withdrawl). This state is characterized by a subject’s inability to achieve restful sleep, sensitivity to light and sound, overall discomfort/lethargy and loss of focus.
- It safeguards against alcohol-induced liver damage. Large amounts of alcohol are toxic to the liver. Studies have shown that groups given Holvenia Dulcis experienced less liver damage when injected with alcohol than groups not receiving Holvenia Dulcis.
Additional BoozAid Ingredients**
- Milk Thistle has been used for over two thousand years due to its remarkable cleansing and support of the liver. Research has proven that thistle helps with:
- The detoxification of poisons—such as alcohol
- The regeneration of damaged liver tissue
- Improved digestion
- N-acytel-cysteine (NAC) is a compound that breaks down acetaldehyde (which is up to 30 times more toxic than alcohol). It also contains glutathione, a powerful antioxidant that is crucial for liver detoxification.
B Vitamins / Thiamine
NAC is thought to work even better when combined with thiamine (also known as vitamin B6). Vitamin B6 may also help lessen hangover symptoms. Since alcohol depletes vitamin B in the body, and B vitamins are required to help eliminate alcohol from the body, a B-vitamin supplement should be taken beforehand, as well as the next day.
Ingesting glutamine will help to minimize reaction known as glutamine rebound.
Alcohol inhibits glutamine, a natural stimulant in your body. This is partly why alcohol has a depressive effect that may make you fall asleep easily… at first. After you’ve stopped drinking, your body will work overtime increasing glutamine levels, which is why you’ll ultimately wake up more often and have a more restless night’s sleep after you drink. Glutamine rebound may contribute to the fatigue, tremors, anxiety, restlessness, and even increased blood pressure that are often felt during a hangover.
Magnesium is another nutrient depleted by alcohol, and it’s one in which many are already deficient. Plus, magnesium has anti-inflammatory properties that may help to reduce certain hangover symptoms such as pounding headache.
Acerole Berry Extract
Acerole Berry Extract is very high in vitamins A and C. It also contains thiamine and riboflavin, which are known to be natural energy boosters.
Schisandra Fruit Extract
Schisandra Fruit Extract is an adaptogen (a natural substance considered to help the body adapt to stress) with anti-aging benefits and protection against liver poison. Helps defend the body from insomnia, erectile dysfunction, exhaustion, excess urination, depression, irritability and memory loss.
Bupleurum Root Powder
Bupleurum Root Powder has been known to combat fatigue, headaches, insomnia and depression. It also assists in protecting the liver.
Artichoke Leaf Powder (Cilarin)
Artichoke Leaf Powder is ideal for hangovers as it decreases nausea and vomiting.
Kudzu Powder is beneficial in boosting the metabolism and detoxifying. Studies have also shown that kudzu can curb the craving for alcohol and lessen symptoms of alcohol withdrawal.
NAD (Nicotinamide adenine dinucleotide)
NAD is a co-enzyme known to significantly reduce the toxic effects of alcohol on the brain and liver. It has even been documented for improving mental function in people with Alzheimer’s; Other studies have shown it to play a role in relieving the symptoms of depression; and depression is a notorious side effect of excessive drinking.
We invite you to review the following study-related medical and scientific information about The Oriental Raisin Tree*
Du J, He D, Sun LN, Han T, Zhang H, Qin LP, Rahman K. Semen Hoveniae extract protects against acute alcohol-induced liver injury in mice. Pharm Biol. 2010;48:953–8. READ FULL ARTICLE
Kim KH, Chung YT, Lee JH, Park YS, Shin MK, Kim HS, Kim DH, Lee HY. Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China. Korean J Med Crop Sci. 2000;8:225–233. READ FULL ARTICLE
Chen SH, Zhong GS, Li AL, Li SH, Wu LK. Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking. Zhongguo Zhong Yao Za Zhi. 2006;31:1094–1096. READ FULL ARTICLE
Jinle, Xiang, Zhu Wenxue, Li Zhixi, Ling Shengbao. 2012. “Effect of juice and fermented vinegar from Hovenia dulcis peduncles on chronically alcohol-induced liver damage in mice.” Food & function 3 (6): 628-34. doi:10.1039/c2fo10266h. READ FULL ARTICLE
We invite you to review the following study-related medical and scientific information about other BoozAid key ingredients**
Jeffrey G. Wiese, MD; Michael G. Shlipak, MD, MPH; and Warren S. Browner, MD, MPH. The Alcohol Hangover. Ann Intern Med. 2000;132(11):897-902. (“claims Prophylactic vitamin B6 (pyritinol) reduced the number of hangover symptoms by approximately 50% in one study”) READ MORE
Khan MA, Jensen K, Krogh HJ. Alcohol-induced hangover. A double-blind comparison of pyritinol and placebo in preventing hangover symptoms. Q J Stud Alcohol. 1973; 34.1195-201
David Novelli. Metabolic Functions of Pantothenic Acid. Physiological Reviews Published 1 October 1953 Vol. 33 no. 4, 525-543. READ MORE
Elhabib Benlhabib, John I. Baker, Daniel E. Keyler, and Ashok K. Singh. Kudzu Root Extract Suppresses Voluntary Alcohol Intake and Alcohol Withdrawal Symptoms in P Rats Receiving Free Access to Water and Alcohol. Journal of Medicinal Food. June 2004, 7(2): 168-179. doi:10.1089/1096620041224210. READ MORE
Ashok K. Singh, Yin Jiang, Shveta Gupta, Mohamod Younus, and Mohamod Ramzan. Anti-Inflammatory Potency of Nano-Formulated Puerarin and Curcumin in Rats Subjected to the Lipopolysaccharide-Induced Inflammation. Journal of Medicinal Food. October 2013, 16(10): 899-911. doi:10.1089/jmf.2012.0049. READ MORE
David H. Overstreet, Jason E. Kralica, A.Leslie Morrowa, Zhong Z. Mab, Y.W. Zhangb, David Y.W. Lee. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacology Biochemistry and BehaviorVolume 75, Issue 3, June 2003, Pages 619–625. READ MORE
Rong Li, Tao Liang, Qiaoling He, Chao Guo, Lingyuan Xu, Kefeng Zhang, Xiaoqun Duan. Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. International Immunopharmacology Volume 17, Issue 1, September 2013, Pages 71–78. READ MORE
(States “Silymarin, the active principle of the milk thistle Silybum marianum, protects experimental animals against various hepatotoxic substances.”) P. Ferenci, B. Dragosics, H. Dittrich, H. Frank, L. Benda, H. Lochs, S. Meryn, W. Base, B. Schneider. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Journal of Hepatology Volume 9, Issue 1, July 1989, Pages 105-113 READ MORE
Mita D. J. Kerai, Catherine J. Waterfield, Susan H. Kenyon, Daniel S. Asker, John A. Timbrell. REVERSAL OF ETHANOL-INDUCED HEPATIC STEATOSIS AND LIPID PEROXIDATION BY TAURINE: A STUDY IN RATS. Alcohol and Alcoholism, Medical Council on Alcoholism, 1999. READ MORE
Bhupinder P.S. Vohra, Xiang Hui. Improvement of Impaired Memory in Mice by Taurine. Neural Plasticity Volume 7 (2000), Issue 4, Pages 245-259 http://dx.doi.org/10.1155/NP.2000.245 http://www.hindawi.com/journals/np/2000/196049/abs/
Jale Balkan, Öznur Kanbagli, Gülçin Aykaç-Toker, Müjdat Uysal. Taurine Treatment Reduces Hepatic Lipids and Oxidative Stress in Chronically Ethanol-Treated Rats. Biological and Pharmaceutical BulletinVol. 25 (2002) No. 9 P 1231-1233. READ MORE
LU Zheng, ZHANG Jing, GAO Zhao-lan, ZHANG Bo, XU Yong-jie. Protective Effect of Burdock Inulin and Jerusalem Artichoke Inulin against Chronic Alcohol-induced Oxidative Injury in Mice. Food Science. READ MORE
Güldal Mehmetçika, Gül Özdemirlerb, Necla Koçak-Tokerb, Uğur Çevikbaşc, Müjdat Uysal. Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Experim=-\]ental and Toxicologic PathologyVolume 60, Issue 6, 18 September 2008, Pages 475- 480. READ MORE
Rafael Llorach , Juan Carlos Espín , Francisco A. Tomás-Barberán , and Federico Ferraris. Artichoke (Cynara scolymus L.) Byproducts as a Potential Source of Health-Promoting Antioxidant Phenolics. J. Agric. Food Chem., 2002, 50 (12), pp 3458–3464. READ MORE
Green Tea Catechins
Effects of green Tea Catechins (gTC) on the Treatment of Hangover and Prevention of Liver Disease. Over-consumption of alcohol leads to many side-effects such as malnutrition, liver disease, and neuronal disorders and many investigators have tried to identify methods for preventing the side-effects of drinking. This study was carried out to investigate the effect of the beverage contained green tea catechins (gTC) on the alcohol administered rats. We observed that blood alcohol concentration level decreased significantly in plasma. gTC (200 mg/kg) also reduced the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) level of the intoxicated rats. These results suggest that gTC may be useful for the prevention and therapy of hepatotoxic pathogenesis. READ MORE
Be-Jen Wanga, Chu-Ting Liua, Chin-Yin Tsenga, Chien-Ping Wub, Zer-Ran Yu. Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO2 on CCl4-induced liver damage. Food and Chemical ToxicologyVolume 42, Issue 4, April 2004, Pages 609–617. READ MORE
Schuss A.G. et al. Antioxidant Capacity and Other Bioactivities of the Freeze-Dried Amazonian Palm Berry, Euterpe oleraceae Mart. (Acari). J. Agric. Food Chem., 2006, 54 (22), pp 8604–8610. READ MORE
S.-H. Kim, M. H. Joo and S.-H. Yoo. Structural Identification and Antioxidant Properties of Major Anthocyanin Extracted from Omija (Schizandra chinensis) Fruit. Journal of Food Science Volume 74, Issue 2, pages C134–C140, March 2009. READ MORE
R W Hong, J D Rounds, W S Helton, M K Robinson, and D W Wilmore. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg. 1992 Feb; 215(2): 114–119.PMCID: PMC1242397. READ MORE
SERGEY M. ZIMATKIN* and TAMARA I. ZIMATKINA. THIAMINE DEFICIENCY AS PREDISPOSITION TO, AND CONSEQUENCE OF, INCREASED ALCOHOL CONSUMPTION. Alcohol & Alcoholism Vol. 31, No. 4, pp. 421^27, 1996. READ MORE
John S. Markowitza*, Aimee L. McRaeb & Susan C. Sonnet. Oral Nutritional Supplementation for the Alcoholic Patient: A Brief Overview. Annals of Clinical PsychiatryVolume 12, Issue 3, 2000, pages 153-158. READ MORE
Aydin S, et al. N-Acetylcysteine Reduced the Effect of Ethanol on Antioxidant System in Rat Plasma and Brain Tissue. The Tohoku Journal of Experimental MedicineVol. 198 (2002) No. 2 October p. 71-77. READ MORE
Mark F. McCarty. Nutraceutical strategies for ameliorating the toxic effects of alcohol. Medical Hypotheses Volume 80, Issue 4, April 2013, Pages 456–462. READ MORE